Steven
I was looking over the article you posted regarding minocycline and autophagy. Are the levels of minocycline discussed in this article clinically achievable? If they are, then we have another variable in the equation regarding when to use chloroquine. The other variable being zinc. If minocycline levels discussed in this article are clinically achievable, then how chloroquine is utilized might need reexamination to optimize the possible benefits of chloroquine, zinc and minocycline.
I don't consider the in vitro minocycline concentrations used in this study to be achievable. Mostly they used 50 micomolar (uM) for the autophagy studies. Maximum unbound concentration in plasma and cerebrospinal fluid is more like 1-2 uM.
ReplyDeleteThey also studied in in vivo, but the tumors were subcutaneous (not in the brain) and the drug was injected intraperitoneally (not given orally). Not the most convincing study for all these reasons.
Mike, did you have any problems loading this study? 3 out of 10 pages won't load for me on Drive.
ReplyDeleteHi Steven. I have all 10 pages. Thanks for your response to my question.
ReplyDelete